Common use

Istamet (sitagliptin and metformin) is prescribed for the management of type 2 diabetes mellitus. Sitagliptin is a DPP-4 inhibitor that increases incretin hormones, enhancing insulin release and reducing glucagon levels. Metformin decreases glucose production in the liver and improves insulin sensitivity, helping to lower blood sugar levels.

Dosage and direction

Istamet is taken orally, usually twice daily with meals. Swallow the tablets whole with water; do not crush or chew. Dosage depends on kidney function, current therapy, and individual patient needs. Follow your healthcare provider’s instructions carefully.

Precautions

Inform your doctor if you have kidney or liver disease, heart failure, a history of lactic acidosis, or pancreatitis. Monitor blood sugar regularly and maintain a healthy diet and exercise regimen. Report any unusual symptoms such as severe stomach pain, nausea, or persistent vomiting.

Contraindications

Do not use Istamet if allergic to sitagliptin, metformin, or any component of the tablet. It is contraindicated in patients with severe kidney impairment, metabolic acidosis, or a history of lactic acidosis.

Possible side effect

Common side effects include nausea, vomiting, diarrhea, headache, and mild hypoglycemia when combined with other antidiabetic drugs. Serious side effects may include lactic acidosis, pancreatitis, severe hypoglycemia, or allergic reactions. Seek immediate medical attention if severe symptoms occur.

Drug interaction

Istamet may interact with other antidiabetic medications, certain antibiotics, diuretics, corticosteroids, and heart medications. Always inform your healthcare provider about all prescription drugs, over-the-counter products, and supplements you are taking.

Missed dose

If a dose is missed, take it as soon as you remember unless it is close to the next scheduled dose. Do not double the dose.

Overdose

Overdose may cause severe hypoglycemia, nausea, vomiting, or lactic acidosis. Seek immediate medical attention if an overdose is suspected.

Storage

Store Istamet at room temperature, away from moisture, heat, and light. Keep tablets in the original container and out of reach of children.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.